PDpep1.3

Product Description: Pdpe 1.3 is a peptide inhibitor, The main activity is to destroy the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). By interfering with this interaction, PDpep1.3 restores the degradation function of the endocytosomes and lysosomes, thereby reducing alpha-synuclein levels and protecting dopaminergic neurons from alpha-synuclein mediated degradation. Pdpe 1.3 can be used in the study of neurodegenerative diseases and protein-protein interactions[1].

Applications: Neuroscience-Neurodegeneration

Formula: C59H101N17O22

References: [1]Nim S, et al. Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease[J]. Nature Communications, 2023, 14(1): 2150.

Molecular Weight: 1400.53

Research Area: Neurological Disease; Others

Target: α-synuclein

• Artikelnummer: MEXHY-P10404-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P10404-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK