PF-303, CAS 1609465-78-2

Product Description: PF-303 is a potent, oral inhibitor of Bruton's tyrosine kinase (BTK) (IC50=0.64 nM). The melamine portion of PF-303 forms a covalent bond with BTK's Cys481, which is reversible and exhibits a high selectivity compared to irreversible covalent BTK inhibitors. PF-303 can be used to model and study the effects of BTK inhibition on the mature immune system, including effects on B-cell subsets, antibody responses, and T-cell-mediated activation[1][2].

Applications: Cancer-Kinase/protease

Formula: C22H21ClN6O2

References: [1]Benson M J, et al. Modeling the clinical phenotype of BTK inhibition in the mature murine immune system[J]. The Journal of Immunology, 2014, 193(1): 185-197./[2]Schnute M E, et al. Aminopyrazole carboxamide bruton’s tyrosine kinase inhibitors. irreversible to reversible covalent reactive group tuning[J]. ACS Medicinal Chemistry Letters, 2018, 10(1): 80-85.

CAS Number: 1609465-78-2

Molecular Weight: 436.89

Research Area: Others

Target: Btk

• Artikelnummer: MEXHY-164002-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-164002-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK