PHM-27 (human), CAS 87403-73-4

Product Description: PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].

Applications: Metabolism-sugar/lipid metabolism

Formula: C135H214N34O40S

References: [1]N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9./[2]Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84./[3]I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223-8.

CAS Number: 87403-73-4

Molecular Weight: 2985.41

Compound Purity: 98.07

Research Area: Metabolic Disease; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: CGRP Receptor

• Artikelnummer: MEXHY-P1072-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P1072-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK