RS-18286, CAS 109458-76-6

Product Description: RS-18286 is a potent LHRH antagonist studied for its effects on pituitary hormone secretion in sexually active rams. Injection of RS-18286 resulted in an immediate suppression of pulsatile LH secretion, accompanied by a decrease in testosterone levels, while FSH and PRL levels remained unchanged. The duration of LH suppression was dose-related, lasting approximately 4.3 to 31.8 hours for low to high doses, respectively. During the recovery phase, a compensatory increase in LH pulse frequency was observed, suggesting a response to diminished testosterone feedback. Even at the lowest dose, RS-18286 transiently reduced testosterone levels, demonstrating an effect on acute hypothalamic sensitivity to changes in hormonal feedback[1].

Formula: C74H101Cl2N17O14

References: [1]Lincoln GA, et al. Compensatory response of the luteinizing-hormone (LH)-releasing hormone (LHRH)/LH pulse generator after administration of a potent LHRH antagonist in the ram. Endocrinology. 1987 Jun;120(6):2245-50.

CAS Number: 109458-76-6

Molecular Weight: 1523.61

Research Area: Others

Target: Others

• Artikelnummer: MEXHY-P2110-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P2110-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK