Ruxolitinib (Standard), CAS 941678-49-5

Product Description: Ruxolitinib (Standard) is the analytical standard of Ruxolitinib. This product is intended for research and analytical applications. Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3].

Formula: C17H18N6

References: [1]Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115(15), 3109-3117./[2]Verstovsek S, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012, 366(9), 799-807./[3]Tavallai M, et al. Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.Front Oncol. 2016 Jun 13;6:142.

CAS Number: 941678-49-5

Molecular Weight: 306.37

Research Area: Cancer

Target: Apoptosis;Autophagy;JAK;Mitophagy

• Artikelnummer: MEXHY-50856R-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-50856R-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK