SB-332235, CAS 276702-15-9

Product Description: SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells[1][2].

Applications: COVID-19-immunoregulation

Formula: C13H10Cl3N3O4S

References: [1]Podolin PL, et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002;169(11):6435-6444./[2]Schinke C, et al. IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells [published correction appears in Blood. 2015 Jul 16;126(3):425. Barreryo, Laura [corrected to Barreyro, Laura]]. Blood. 2015;125(20):3144-3152.

CAS Number: 276702-15-9

Molecular Weight: 410.66

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: CXCR

• Artikelnummer: MEXHY-16981-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16981-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK