Spadin, CAS 1270083-24-3

Product Description: Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C96H142N26O22

References: [1]Borsotto M, et, al. Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172(3):771-84. /[2]Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.

CAS Number: 1270083-24-3

Molecular Weight: 2012.34

Compound Purity: 99.08

Research Area: Neurological Disease

Solubility: H2O : ≥ 100 mg/mL

Target: 5-HT Receptor;Potassium Channel

• Artikelnummer: MEXHY-P1422-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P1422-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK