Product Description: TAT-AKAP79 326-336 is a cytoosmotic peptide. TAT-AKAP79 326-336 mimics a specific region on the AKAP79 protein that binds to TRPV1 ion channels (amino acid sequence 326-336). TAT-AKAP79 326-336 inhibits the sensitization of TRPV1 and reduce the overresponse of TRPV1 channels to stimuli caused by the activation of cellular kinases such as protein kinase A (PKA) and protein kinase C (PKC) by inflammatory mediators. TAT-AKAP79 326-336 can be used to study the mechanism of pain transduction and inflammatory hyperalgesia[1].
Applications: COVID-19-immunoregulation
Formula: C117H211N49O34S
References: [1]Btesh J, et al. Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia[J]. Journal of Neuroscience, 2013, 33(21): 9184-9193.
Molecular Weight: 2880.30
Research Area: Inflammation/Immunology; Neurological Disease