TG8-260, CAS 2490544-50-6

TG8-260, CAS 2490544-50-6
Artikelnummer
MEXHY-164049-10
Verpackungseinheit
10 mg
Hersteller
MedChemExpress

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Product Description: TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. TG8-260 can reduce neuroinflammation and gliosis in the hippocampus of rats after pilocarpine-induced persistent epileptic status. Pharmacokinetic data of TG8-260 showed that its plasma half-life was 2.14 hours and its oral bioavailability was 77.3%. TG8-260 is also a potent inhibitor of CYP450 and shows antagonistic activity in inhibiting EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglia, which is suitable for studying anti-inflammatory pathways in animal models of peripheral inflammatory diseases[1].

Formula: C21H20N4O

References: [1]Amaradhi R, Mohammed S, Banik A, et al. Second-generation prostaglandin receptor EP2 antagonist, TG8-260, with high potency, selectivity, oral bioavailability, and anti-inflammatory properties[J]. ACS Pharmacology & Translational Science, 2022, 5(2): 118-133.

CAS Number: 2490544-50-6

Molecular Weight: 344.41

Compound Purity: 98.25

Research Area: Inflammation/Immunology

Target: Prostaglandin Receptor
Mehr Informationen
Artikelnummer MEXHY-164049-10
Hersteller MedChemExpress
Hersteller Artikelnummer HY-164049-10
Verpackungseinheit 10 mg
Mengeneinheit STK
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