Product Description: VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P450, exhibits good pharmacokinetic characteristics in rats[1].
Formula: C14H13ClN4O
References: [1]Capstick R A, et al. Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile[J]. ACS Medicinal Chemistry Letters, 2024.
CAS Number: 2170550-99-7
Molecular Weight: 288.73
Research Area: Neurological Disease
Target: Cytochrome P450;mAChR