YM-344031, CAS 671204-98-1

YM-344031, CAS 671204-98-1
Artikelnummer
MEXHY-160998-0
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MedChemExpress

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Product Description: YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC50 of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca[2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model[1].

Applications: COVID-19-immunoregulation

Formula: C29H31FN4O3

References: [1]Suzuki K, et al., In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1217-23.

CAS Number: 671204-98-1

Molecular Weight: 502.58

Research Area: Inflammation/Immunology

Target: CCR
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Artikelnummer MEXHY-160998-0
Hersteller MedChemExpress
Hersteller Artikelnummer HY-160998-0
Verpackungseinheit Get quote
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