PS-10, CAS 1564265-82-2

Formulation: A solid

Formal Name: 2-[(2,4-dihydroxyphenyl)sulfonyl]-2,3-dihydro-1H-isoindole-4,6-diol

Purity: ≥98%

Formula Markup: C14H13NO6S

Formula Weight: 323,3

Shelf life (days): 1460

CAS Number: 1564265-82-2

Notes: PS-10 is an inhibitor of pyruvate dehydrogenase kinase (PDHK; IC50s = 2.07, 0.8, 21.3, and 0.77 µM for PDHK1, -2, -3, and -4, respectively).{67928} It selectively binds to PDHK2 over heat shock protein 90 (Hsp90; Kds = 0.239 and 47 µM, respectively). PS-10 (70 mg/kg) increases heart, liver, and kidney pyruvate dehydrogenase complex activity, decreases blood glucose levels in a glucose tolerance test, and reduces plasma lactate, cholesterol, and triglyceride levels, fat mass, and hepatic lipid accumulation in a mouse model of high-fat diet-induced obesity.

• Artikelnummer: CAY42068-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42068-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK