5β,6β-epoxycholestanol, CAS 4025-59-6

Product Description: 5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue[1][2][3].

Formula: C27H46O2

References: [1]Pulfer M K, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant[J]. Journal of Biological Chemistry, 2004, 279(25): 26331-26338./[2]Aringer L, et al. Formation and metabolism in vitro of 5, 6-epoxides of cholesterol and 尾-sitosterol[J]. Journal of Lipid Research, 1974, 15(4): 389-398./[3]Garcia-Cruset S, et al. Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions. Free Radic Res. 2001 Jul;35(1):31-41.

CAS Number: 4025-59-6

Molecular Weight: 402.65

Compound Purity: 99.0

Research Area: Others

Solubility: Ethanol : 20 mg/mL (ultrasonic;warming)

Target: Biochemical Assay Reagents

• Artikelnummer: MEXHY-130502-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130502-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK