Product Description: BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD)[1][2][3].
Formula: C20H10N2Na2O4
References: [1]Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25(9):2158-63./[2]Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056./[3]Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8(10):637.
CAS Number: 979-88-4
Molecular Weight: 388.28
Compound Purity: 99.93
Research Area: Cancer; Neurological Disease
Solubility: DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 100 mg/mL (ultrasonic)
Target: Beta-secretase