Carbamylated Core Histones (bovine)

Formulation: Lyophilized from a solution in PBS, pH 7.4

Shelf life (days): 730

Notes: Citrullination and carbamylation are two post-translational modifications that result in the generation of citrulline and homocitrulline, two highly related, non-standard amino acids. While citrullination of arginine is catalyzed by peptidylarginine deiminases (PADs), homocitrulline results from the non-enzymic reaction of cyanate with lysine. Carbamylation occurs at low levels in healthy individuals, but at higher levels in several clinical conditions such as atherosclerosis, kidney disease, and inflammation.{33133,33134,33135} Carbamylation can lead to changes in protein function, cellular function, and generation of an immune response to homocitrulline containing proteins.{33133,33134,33135} This product contains a carbamylated mixture of H1, H2A, H2B, H3, and H4 histones isolated from calf thymus.

• Artikelnummer: CAY21076
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21076-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Western Blotting, ELISA