Formulation: Lyophilized from a solution in PBS, pH 7.4, 200 μg per vial. Reconstitution with 0.2 ml of water will yield 1 mg/ml solution in 1X PBS.
Shelf life (days): 730
Notes: Advanced glycation end products (AGEs) are formed from the nonenzymatic reaction of amino groups with reducing sugars.{38175, 38176, 38177} AGEs have been implicated in diseases, such as diabetes mellitus, non-diabetic nephropathy, macrovascular disease, Alzheimer’s disease, cataract, and ageing. {38175, 38176, 38177} AGE receptors, such as the receptor for AGE (RAGE), mediate biological responses to AGEs, including endocytic uptake and degradation and induction of cytokines and growth factors.{38175, 38176, 38177} CML-BSA was produced by incubating BSA with glyoxylic acid and sodium cyanoborohydride.