Lipopolysaccharides

Product Description: Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells[1][2][3]. This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome[4].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404./[2]Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32./[3]Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337./[4]Gayle DA, et al. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res Dev Brain Res. 2002 Jan 31;133(1):27-35./[5]Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433.

Molecular Weight: N/A

Research Area: Inflammation/Immunology

Solubility: H2O : 5 mg/mL (ultrasonic)/DMSO : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Toll-like Receptor (TLR)

• Artikelnummer: MEXHY-D1056-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-D1056-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK