Serpin B9-IN-1, CAS 154235-77-5

Product Description: Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1].

Applications: Cancer-programmed cell death

Formula: C8H5NO3

References: [1]Huang Y, et al. Mass Spectrometry-Based Proteomics Identifies Serpin B9 as a Key Protein in Promoting Bone Metastases in Lung Cancer. Mol Cancer Res. 2024 Apr 2;22(4):402-414.

CAS Number: 154235-77-5

Molecular Weight: 163.13

Compound Purity: 98.0

Research Area: cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Biochemical Assay Reagents

• Artikelnummer: MEXHY-33299-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-33299-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK