Rift Valley Fever Virus L Protein (TAN/Dod-002/07) (recombinant)

Formulation: Lyophilized from sterile PBS, pH 7.4

Purity: ≥90% as estimated by SDS-PAGE

Formula Weight: 0

Shelf life (days): 365

Notes: Rift Valley fever virus (RVFV) is a single-stranded negative-sense RNA virus, member of the Phlebovirus genus, and mosquito-transmitted pathogen endemic to sub-Saharan Africa and the Arabian peninsula.{69742,69740,69741} The tripartite RNA genome of RVFV is composed of three segments: L, which encodes L protein, a single-polypeptide RNA-dependent RNA polymerase (RdRp), M, which encodes a single open reading frame (ORF) that produces the envelope glycoproteins Gn and Gc and non-structural proteins NSm and Gn/NSm fusion protein, and S, which is ambisense, encoding the nucleoprotein N in the genomic sense orientation, and the non-structural protein and major virulence factor NSs in the antigenomic orientation.{69741,69740} RVFV L protein is composed of an N-terminal endonuclease domain linked to a PA-C-like domain, an RdRp core, a PB2-N-like domain, a CBD domain, and a C-terminal lariat domain.{68718} The N-terminal endonuclease domain is essential for cap-snatching during host mRNA transcription, and the RdRp core is essential for viral RNA production. Expression of a dominant-negative L protein mutant inhibits viral gene expression in RVFV-infected BHK/T7-9 cells.{68719} Cayman’s Rift Valley Fever Virus L protein (TAN/Dod-002/07) (recombinant) consists of 256 amino acids and has a calculated molecular weight of 29.4 kDa.

• Artikelnummer: CAY40856-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40856-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK