SET2, CAS 2313525-20-9

Formulation: A solid

Formal Name: N-(2-furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-propanamide

Purity: ≥98%

Formula Markup: C17H21F3N4O2S

Formula Weight: 402,4

Shelf life (days): 1460

CAS Number: 2313525-20-9

Notes: SET2 is an inhibitor of transient receptor potential vanilloid 2 (TRPV2; IC50 = 0.46 µM).{68701} It selectively inhibits currents induced by the TRP channel modulator 2-APB (Item No. 64970) in a patch-clamp assay using HEK293T cells overexpressing TRPV2 at 0.3 or 1 µM over HEK293T cells overexpressing TRPV1 or TRPV3 at 3 or 10 µM. SET2 (20 µM) reduces migration induced by lysophosphatidic acid (LPA) in PC-3M prostate cancer cells to a similar extent as the LPA receptor 1 (LPA1) antagonist AM966 (Item No. 22048). It also reduces LPA-induced increases in current in a patch-clamp assay using HEK293T cells when used at a concentration of 10 µM.

• Artikelnummer: CAY40360-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40360-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK