Shepherdin (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-lysyl-L-histidyl-L-seryl-L-serylglycyl-L-cysteinyl-L-alanyl-L-phenylalanyl-L-leucine, trifluoroacetate salt

Purity: ≥90%

Formula Markup: C41H64N12O12S • XCF3COOH

Formula Weight: 949,1

Shelf life (days): 1460

Notes: Shepherdin is a synthetic peptide that corresponds to amino acids 79-87 of human survivin and an inhibitor of the protein-protein interaction between survivin and heat shock protein 90 (Hsp90).{65823} It binds to the N-terminal domain of Hsp90 in a concentration-dependent manner and inhibits the interaction between recombinant human survivin and Hsp90 in isolated human reticulocyte extracts when used at a concentration of 150 µM. Peptide conjugates of shepherdin with the cell-permeable peptides penetratin (Item No. 36878) or HIV Tat sequence have anticancer activity in vitro and in vivo.

• Artikelnummer: CAY38327-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38327-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK