3',4'-Dihydroxyflavone, CAS 4143-64-0

Formulation: A crystalline solid

Formal Name: 2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥95%

Formula Markup: C15H10O4

Formula Weight: 254,2

Shelf life (days): 1460

CAS Number: 4143-64-0

Notes: 3',4'-Dihydroxyflavone is a synthetic flavonoid that has diverse biological activities.{28716,60976,64383,64384} It inhibits tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.23 and 0.17 µM for the human enzymes, respectively).{28716} 3',4'-Dihydroxyflavone is active against L. donovani, T. brucei, and T. cruzi with IC50 values of 2, 1.1, and 10.1 µg/ml, respectively.{60976} It induces apoptosis in and inhibits migration of GL15 glioblastoma cells when used at a concentration of 50 µM.{64383} 3',4'-Dihydroxyflavone (5 mg/kg) prevents LPS-induced increases in brain levels of COX-2 and inducible nitric oxide synthase (iNOS) in a mouse model of neuroinflammation.{64384}

• Artikelnummer: CAY35226-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35226-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK
• Methode: Reinstoffe