3′-Deoxy-3′-fluorothymidine, CAS 25526-93-6

Formulation: A solid

Formal Name: 3'-deoxy-3'-fluoro-thymidine

Purity: ≥98%

Formula Markup: C10H13FN2O4

Formula Weight: 244,2

Shelf life (days): 1460

CAS Number: 25526-93-6

Notes: 3′-Deoxy-3′-fluorothymidine is a nucleoside analog.{61967} It is phosphorylated by thymidine kinase 1 (TK1) but not TK2 and also inhibits TK1 and TK2 (Kis = 6 and 10 µM, respectively). 3′-Deoxy-3′-fluorothymidine inhibits HIV-1 reverse transcriptase (EC50 = 5 nM) and the replication of HIV-1 in MT-4 human T cell leukemia cells (EC50 = 5 nM).{61968} It decreases mitochondrial DNA (mtDNA) levels and the oxygen consumption rate (OCR) and induces upregulation of the cell differentiation marker CD11b in OCI-AML-2 and MV4-11 acute myeloid leukemia (AML) cells in a concentration-dependent manner.{61969} 3′-Deoxy-3′-fluorothymidine (50 mg/kg) reduces tumor growth in an OCI-AML-2 AML mouse xenograft model. A radiolabeled form of 3′-deoxy-3′-fluorothymidine, [18F]FLT, is commonly used as a PET tracer for in vivo imaging of tumors.{61970}

• Artikelnummer: CAY36519-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36519-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe