3-Isomangostin, CAS 19275-46-8

Formulation: A solid

Formal Name: 3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one

Purity: ≥98%

Formula Markup: C24H26O6

Formula Weight: 410,5

Shelf life (days): 1460

CAS Number: 19275-46-8

Notes: 3-Isomangostin is a xanthone and α-mangostin (Item No. 29108) derivative that has been found in G. mangostana and has diverse biological activities.{64507,64508,64509,64510,64511,64512} It is an inhibitor of mutT homolog 1 (MTH1; IC50 = 52 nM).{64507} 3-Isomangostin also inhibits aldose reductase (IC50 = 3.48 µM), acetylcholinesterase (AChE; IC50 = 2.36 µg/ml), and butyrylcholinesterase (BChE; IC50 = 5.32 µg/ml).{64508,64509} It inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 µg/ml, respectively).{64510} 3-Isomangostin inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively).{64511,64512}

• Artikelnummer: CAY36484-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36484-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe