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4-iodo-SAHA , CAS 1219807-87-0
4-iodo-SAHA , CAS 1219807-87-0
Artikelnummer
BPS27205
Verpackungseinheit
50 mg
Hersteller
BPS Bioscience
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Biological Activity: 4-iodo-SAHA inhibits SKBR3 breast-derived and HT29 colon-derived cell line proliferation with EC50 values comparable to that of SAHA (1.1 µM and 0.95 µM versus 2.1 µM and 2 µM, respectively). It has 10 times the inhibition strength of U937 leukemia cell proliferation in comparison to SAHA (0.12 µM versus 1.2 µM, respectively).
CAS Number: 1219807-87-0
Description: 4-iodo-SAHA is a hydrophobic derivative of SAHA, a class I and class II histone deacetylase (HDAC) inhibitor. Similar to SAHA, it demonstrates > 60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay at 1 µM.
Format: A crystalline solid
Purity: ≥98% by HPLC
Solubility: Solubility in ethanol is 0.2 mg/ml and 30 mg/ml in DMSO and DMF. First, dissolve in DMSO then dilute with the aqueous buffer of choice.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Salmi-Smail, C., et al., J. Med. Chem. 2010; 53: 3038 - 3047.
Biological Activity: 4-iodo-SAHA inhibits SKBR3 breast-derived and HT29 colon-derived cell line proliferation with EC50 values comparable to that of SAHA (1.1 µM and 0.95 µM versus 2.1 µM and 2 µM, respectively). It has 10 times the inhibition strength of U937 leukemia cell proliferation in comparison to SAHA (0.12 µM versus 1.2 µM, respectively).
CAS Number: 1219807-87-0
Description: 4-iodo-SAHA is a hydrophobic derivative of SAHA, a class I and class II histone deacetylase (HDAC) inhibitor. Similar to SAHA, it demonstrates > 60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay at 1 µM.
Format: A crystalline solid
Purity: ≥98% by HPLC
Solubility: Solubility in ethanol is 0.2 mg/ml and 30 mg/ml in DMSO and DMF. First, dissolve in DMSO then dilute with the aqueous buffer of choice.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Salmi-Smail, C., et al., J. Med. Chem. 2010; 53: 3038 - 3047.
| Artikelnummer | BPS27205 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27205 |
| Green Labware | Nein |
| Verpackungseinheit | 50 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
