5-Aminosalicylic Acid-d7

Formulation: A solid

Formal Name: 5-(amino-d2)-2-(hydroxy-d)benzoic-d3 acid-d

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C7D7NO3

Formula Weight: 160,2

Shelf life (days): 1460

Notes: 5-Aminosalicylic acid-d7 (5-ASA-d7) is intended for use as an internal standard for the quantification of 5-ASA (Item No. 70265) by GC- or LC-MS. 5-ASA is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulphasalazine (Item No. 15025), basalazide (Item No. 18680), and olsalazine (Item No. 23661).{8427} It selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC50s = 61 and 410 µM, respectively). 5-ASA inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC50 = 50 µM).{64642} It also inhibits the synthesis of leukotriene B4 (LTB4; Item No. 20110) in isolated human mucosal cells when used at a concentration of 100 µM.{8429} Formulations containing 5-ASA have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.

• Artikelnummer: CAY37197-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37197-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung