8-Methoxymethyl-3-isobutyl-1-methylxanthine, CAS 78033-08-6

Formulation: A solid

Formal Name: 3,9-dihydro-8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

Purity: ≥98%

Formula Markup: C12H18N4O3

Formula Weight: 266,3

Shelf life (days): 1460

CAS Number: 78033-08-6

Notes: 8-Methoxymethyl-3-isobutyl-1-methylxanthine is an inhibitor of phosphodiesterase 1 (PDE1; IC50 = 5 µM) and a derivative of IBMX (Item No. 13347).{69393} It is selective for PDE1 over PDE2, PDE3, and PDE4 but also inhibits PDE5 (IC50s = 37, >400, >400, and 2 µM, respectively). 8-Methoxymethyl-3-isobutyl-1-methylxanthine (30 µM) enhances forskolin-induced increases in intracellular calcium levels in isolated rat olfactory receptor neurons.{69394} It induces relaxation of isolated human saphenous vein segments in the absence of endothelium (EC50 = 31 µM).{69395} In vivo, 8-methoxymethyl-3-isobutyl-1-methylxanthine (200 µg/kg) enhances decreases in pulmonary artery pressure and vascular resistance induced by iloprost (Item No. 18215) in a rabbit model of pulmonary hypertension induced by the TP receptor agonist U-46619 (Item No. 16450).{69396}

• Artikelnummer: CAY39151-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39151-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK