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ABT-888 (Veliparib) , CAS 912444-00-9
ABT-888 (Veliparib) , CAS 912444-00-9
Artikelnummer
BPS27101
Verpackungseinheit
10 mg
Hersteller
BPS Bioscience
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Biological Activity: ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Ki of 5.2 nmol/L and 2.9 nmol/L, respectively. ABT-888 inhibited PARP-1 with IC50 of 4.4 nM using BPS Bioscience PARP1 Chemiluminescent Assay Kit (Cat. #80551).
CAS Number: 912444-00-9
Description: ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2. In the MX-1 breast xenograft model (BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide, causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited.
Format: White to beige powder.
Purity: ≥99% by HPLC
Solubility: Soluble in DMSO.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Donawho, C. K., et al., Clinical Cancer Research May 2007 13; 2728.
2. Sanchez, E. V., et al., Meeting: 2009 ASCO Annual Meeting. Citation: J Clincal Oncol.27: 15s, 2009 (suppl; abstr 11028).
3. Liu, SK., et al., Radiother Oncol. 2008 Aug; 88(2): 258-68.
Biological Activity: ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Ki of 5.2 nmol/L and 2.9 nmol/L, respectively. ABT-888 inhibited PARP-1 with IC50 of 4.4 nM using BPS Bioscience PARP1 Chemiluminescent Assay Kit (Cat. #80551).
CAS Number: 912444-00-9
Description: ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2. In the MX-1 breast xenograft model (BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide, causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited.
Format: White to beige powder.
Purity: ≥99% by HPLC
Solubility: Soluble in DMSO.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Donawho, C. K., et al., Clinical Cancer Research May 2007 13; 2728.
2. Sanchez, E. V., et al., Meeting: 2009 ASCO Annual Meeting. Citation: J Clincal Oncol.27: 15s, 2009 (suppl; abstr 11028).
3. Liu, SK., et al., Radiother Oncol. 2008 Aug; 88(2): 258-68.
| Artikelnummer | BPS27101 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27101 |
| Green Labware | Nein |
| Verpackungseinheit | 10 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
