Afatinib, CAS 850140-72-6

Formulation: A crystalline solid

Formal Name: (2E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Purity: ≥95%

Formula Markup: C24H25ClFN5O3

Formula Weight: 485,9

Shelf life (days): 1460

CAS Number: 850140-72-6

Notes: Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively).{33871} It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein.{42401} Afatinib (20 mg/kg) reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models.{42402} Formulations containing afatinib have been used in the treatment of non-small cell lung cancer.

• Artikelnummer: CAY11492-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11492-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK