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Alvespimycin HCl (17-DMAG) , CAS 467214-21-7
Alvespimycin HCl (17-DMAG) , CAS 467214-21-7
Artikelnummer
BPS27730-1
Verpackungseinheit
25 mg
Hersteller
BPS Bioscience
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Background: Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
Biological Activity: Alvespimycin (also known as 17-DMAG) displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM.
CAS Number: 467214-21-7
Description: Alvespimycin HCl, also known as 17-DMAG, is a potent, water-soluble HSP90 inhibitor. Alvespimycin has diverse anti-tumor actions and has potential in treating a number of different types of cancers, including ovarian, prostate, melatnoma, non-small-cell lung cancer, and several leukemias (chronic lymphocytic, acute myeloid). This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.
Purity: ≥95% by HPLC
Solubility: Soluble in DMSO (100 mM). Solubility in water is less than 1 mg/ml (1 mM).
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: HSP90
Biosafety Level: Not applicable (BSL-1)
References: 1. Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126.
2. Lancet JE, et al. 2010 Apr;24(4):699-705.
Background: Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
Biological Activity: Alvespimycin (also known as 17-DMAG) displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM.
CAS Number: 467214-21-7
Description: Alvespimycin HCl, also known as 17-DMAG, is a potent, water-soluble HSP90 inhibitor. Alvespimycin has diverse anti-tumor actions and has potential in treating a number of different types of cancers, including ovarian, prostate, melatnoma, non-small-cell lung cancer, and several leukemias (chronic lymphocytic, acute myeloid). This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.
Purity: ≥95% by HPLC
Solubility: Soluble in DMSO (100 mM). Solubility in water is less than 1 mg/ml (1 mM).
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: HSP90
Biosafety Level: Not applicable (BSL-1)
References: 1. Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126.
2. Lancet JE, et al. 2010 Apr;24(4):699-705.
| Artikelnummer | BPS27730-1 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27730-1 |
| Green Labware | Nein |
| Verpackungseinheit | 25 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
