Apricitabine, CAS 160707-69-7

Formulation: A solid

Formal Name: 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone

Purity: ≥95%

Formula Markup: C8H11N3O3S

Formula Weight: 229,3

Shelf life (days): 1460

CAS Number: 160707-69-7

Notes: Apricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) and derivative of 2’-deoxycytidine (Item Nos. 34708 / 30125).{65152} It is phosphorylated intracellularly to its active form, apricitabine-5’-triphosphate, which competes with a monophosphate form for binding to HIV-1 reverse transcriptase and incorporation into the nascent viral DNA, inducing chain termination and HIV-1 replication. Apricitabine reduces HIV-1 infectivity in MT-4 and U937 cells (IC50s = 2.8 and 0.4 µM, respectively), as well as in isolated human cord blood mononuclear cells (CBMCs; IC50 = 0.4 µM).{65153}

• Artikelnummer: CAY36037-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36037-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe