AS-1842856, CAS 836620-48-5

Formulation: A crystalline solid

Formal Name: 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Purity: ≥98%

Formula Markup: C18H22FN3O3

Formula Weight: 347,4

Shelf life (days): 1460

CAS Number: 836620-48-5

Notes: AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells).{37141} Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.{37142},{37143}

• Artikelnummer: CAY16761-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16761-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe