Azacytidine (Vidaza) , CAS 320-67-2

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Biological Activity: When testing anti-tumor effects in prostate cancer the antiproliferative effect of azacitidine treatment in 22rv1 cells and PC3 cells, the IC50's were 0.5 µM and 2.5 µM respectively.

CAS Number: 320-67-2

Description: Azacitidine is also known as Vidaza, 5-azacytidine, Mylosar, and Ladakamycin. Azacitidine and its deoxy derivative, decitabine (5-aza-2'deoxycytidine), are used in the treatment of myelodysplastic syndrome. The azacytidine in the DNA forms a stable complex with DNA methyltransferase enzymes, preventing DNMT activity and resulting in hypomethylation of cellular DNA. Likewise, the incorporation of azacytidine into RNA leads to the dissembly of polyribosomes, defective methylation and inhibition of protein production with subsequent cytotoxicity.

Format: White to off-white solid

Purity: ≥99% by HPLC

Solubility: Soluble in DMSO. Insoluble in acetone, ethanol, and methyl ethyl ketone. Slightly soluble inethanol/water combination of fifty-fifty, and propylene glycol.

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: Vigushin DM et al. Clin Cancer Res. 2001 Apr;7(4):971-6.

• Artikelnummer: BPS27107
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27107
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK