Belotecan (hydrochloride), CAS 213819-48-8

Formulation: A solid

Formal Name: (4S)-4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, monohydrochloride

Purity: ≥95%

Formula Markup: C25H27N3O4 • HCl

Formula Weight: 470

Shelf life (days): 1460

CAS Number: 213819-48-8

Notes: Belotecan is an inhibitor of DNA topoisomerase I (IC50 = 0.119 µg/ml) and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{58975} It inhibits the proliferation of various cancer cell lines, including KATO III stomach, HT-29 colon, A549 lung, MDA-MB-231 breast, and SKOV3 ovarian cancer cells (IC50s = 160, 10.9, 9, 345, and 31 ng/ml, respectively). Belotecan (150 ng/ml) induces apoptosis and cell cycle arrest at the G2/M phase in, and inhibits invasion of, SiHa cervical cancer cells.{58976} It reduces tumor growth in a Ca Ski cervical cancer mouse xenograft model when administered at a dose of 25 mg/kg. Belotecan (80 µg/kg) reduces food intake and body weight in pregnant dams and increases fetal deaths and decreases litter size.{58977} Formulations containing belotecan have been used in the treatment of ovarian and small cell lung cancer.

• Artikelnummer: CAY35488-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35488-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe