Bemcentinib (GMP), CAS 1037624-75-1

Product Description: Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC50 of 14 nM[1][2].

Applications: Cancer-Kinase/protease

Formula: C30H34N8

References: [1]Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64./[2]Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57./[3]Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54.

CAS Number: 1037624-75-1

Molecular Weight: 506.64

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: TAM Receptor

• Artikelnummer: MEXHY-15150G-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15150G-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK