Blarcamesine, CAS 195615-83-9

Formulation: A crystalline solid

Formal Name: tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine

Purity: ≥98%

Formula Markup: C19H23NO

Formula Weight: 281,4

Shelf life (days): 1460

CAS Number: 195615-83-9

Notes: Blarcamesine is an agonist of the sigma non-opioid intracellular receptor 1 (σ1 receptor).{69398} It inhibits reductions in mitochondrial oxygen consumption and lipid peroxidation induced by amyloid-β (Aβ) (25-35) (Aβ (25-35)) in isolated mouse hippocampus when administered at a dose of 1 mg/kg. Blarcamesine (1 mg/kg) improves deficits in novel object recognition induced by Aβ (25-35) in mice, as well as reduces tau phosphorylation and Aβ (1-42) levels in the hippocampus in the same model.{32115} It increases the latency to fall in the rotarod test, reduces gait impairments, and reduces increases in the mean acoustic startle response in an Mecp2-/- mouse model of Rett syndrome, an X-linked neurodevelopmental disorder, when administered at a dose of 30 mg/kg per day.{69399}

• Artikelnummer: CAY36812-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36812-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK