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Bortezomib , CAS 179324-69-7
Bortezomib , CAS 179324-69-7
Artikelnummer
BPS27028
Verpackungseinheit
10 mg
Hersteller
BPS Bioscience
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CAS Number: 179324-69-7
Description: Potent (Ki, 0.6 nM), specific and reversible proteasome inhibitor; no significant inhibitory activity against other enzymes or receptors. Bortezomib inhibits cell proliferation of H460 cells (human non-small cell lung cancer cell lines) with an IC50 of 0.1 µM and has been associated with suppresion of prostate cancer cell lines with an IC90 of 10 nM.
Format: White to off-white solid.
Purity: ≥99%
Solubility: Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Warnings: Protect from light. Hygroscopic. Protect from moisture.
Biosafety Level: Not applicable (BSL-1)
References: 1. Bouchard, PR., et al. 55th Annual Meeting of the American College of Veterinary Pathologists (ACVP) & 39th Annual Meeting of the American Society of Clinical Pathology (ASVCP), ACVP and ASVCP (Eds.) (2004).
2. Ling, Y., et al. Clin. Cancer Res. 9: 1145-1154 (2003).
3. Williams, S., et al. Mol. Cancer Ther. 2: 835-843 (2003).
CAS Number: 179324-69-7
Description: Potent (Ki, 0.6 nM), specific and reversible proteasome inhibitor; no significant inhibitory activity against other enzymes or receptors. Bortezomib inhibits cell proliferation of H460 cells (human non-small cell lung cancer cell lines) with an IC50 of 0.1 µM and has been associated with suppresion of prostate cancer cell lines with an IC90 of 10 nM.
Format: White to off-white solid.
Purity: ≥99%
Solubility: Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Warnings: Protect from light. Hygroscopic. Protect from moisture.
Biosafety Level: Not applicable (BSL-1)
References: 1. Bouchard, PR., et al. 55th Annual Meeting of the American College of Veterinary Pathologists (ACVP) & 39th Annual Meeting of the American Society of Clinical Pathology (ASVCP), ACVP and ASVCP (Eds.) (2004).
2. Ling, Y., et al. Clin. Cancer Res. 9: 1145-1154 (2003).
3. Williams, S., et al. Mol. Cancer Ther. 2: 835-843 (2003).
| Artikelnummer | BPS27028 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27028 |
| Green Labware | Nein |
| Verpackungseinheit | 10 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
