BRD0705, CAS 2056261-41-5

Formulation: A solid

Formal Name: (4S)-4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-5H-pyrazolo[3,4-b]quinolin-5-one

Purity: ≥98%

Formula Markup: C20H23N3O

Formula Weight: 321,4

Shelf life (days): 1460

CAS Number: 2056261-41-5

Notes: BRD0705 is an inhibitor of glycogen synthase kinase 3α (GSK3α; IC50 = 66 nM).{68302} It is selective for GSK3α over GSK3β (IC50 = 515 nM). BRD0705 (10 and 20 µM) inhibits GSK3α autophosphorylation in U937 cells. It impairs colony formation of MOLM-13, TF-1, U937, MV4-11, HL-60, and NB4 acute myeloid leukemia (AML) cells. In vivo, BRD0705 (30 mg/kg) inhibits leukemia development in secondary recipient mice in an MLL-AF9 mouse syngeneic tumor model.

• Artikelnummer: CAY37314-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37314-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK