Brefeldin A, CAS 20350-15-6

Formulation: A crystalline solid

Formal Name: (1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one

Purity: ≥98%

Formula Markup: C16H24O4

Formula Weight: 280,4

Shelf life (days): 1460

CAS Number: 20350-15-6

Notes: Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum.{21254,21256,21248} BFA directly and reversibly inhibits Sec7 domain-containing guanine-exchange factors which are necessary for ADP-ribosylation factor activation associated with vesicular transport (IC50 = ~10 μM).{21253,21252,21247} BFA is used to study endosomal trafficking and function in cells of plants as well as those of fungi, invertebrates, and vertebrates.{21250,21251}

• Artikelnummer: CAY11861-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11861-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK