Brinzolamide, CAS 138890-62-7

Formulation: A crystalline solid

Formal Name: 4R-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-1,1-dioxide-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide

Purity: ≥98%

Formula Markup: C12H21N3O5S3

Formula Weight: 383,5

Shelf life (days): 1460

CAS Number: 138890-62-7

Notes: Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively).{53202} It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure (IOP) in a rabbit model of spontaneous ocular hypertension. It also reduces IOP in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.

• Artikelnummer: CAY11660-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11660-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK