BRM/BRG1 ATP Inhibitor 1, CAS 2270879-17-7

Formulation: A solid

Formal Name: N-[3-(difluoromethyl)-5-isothiazolyl]-N′-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-urea

Purity: ≥98%

Formula Markup: C11H9F3N4O2S

Formula Weight: 318,3

Shelf life (days): 1460

CAS Number: 2270879-17-7

Notes: BRM/BRG1 ATP inhibitor 1 is an allosteric dual inhibitor of brahma homologue (BRM), also known as SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2), and brahma-related gene 1 (BRG1), also known as SMARCA4, ATPase activities (IC50s = <0.005 µM for both).{62762} It reduces the expression of keratin 80 (KRT80) in H1299 and RERF-LC-A1 cells. BRM (20mg/kg) reduces tumor growth in a RERF-LC-A1 lung cancer mouse xenograft model.

• Artikelnummer: CAY36138-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36138-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: LC-MS