Formulation: A solid
Formal Name: α-amino-α-(4-boronobutyl)-1-[(2,4-dichlorophenyl)methyl]-4-piperidineacetic acid
Purity: ≥95%
Formula Markup: C18H27BCl2N2O4
Formula Weight: 417,1
Shelf life (days): 1460
CAS Number: 1345810-21-0
Notes: CB-1158 is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively).{35829} It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS; IC50s = >50 µM for all). CB-1158 reverses inhibition of T cell proliferation induced by granulocytes in vitro (IC50 = 0.204 µM). It reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 100 mg/kg twice per day.