CB-1158, CAS 1345810-21-0

Formulation: A solid

Formal Name: α-amino-α-(4-boronobutyl)-1-[(2,4-dichlorophenyl)methyl]-4-piperidineacetic acid

Purity: ≥95%

Formula Markup: C18H27BCl2N2O4

Formula Weight: 417,1

Shelf life (days): 1460

CAS Number: 1345810-21-0

Notes: CB-1158 is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively).{35829} It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS; IC50s = >50 µM for all). CB-1158 reverses inhibition of T cell proliferation induced by granulocytes in vitro (IC50 = 0.204 µM). It reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 100 mg/kg twice per day.

• Artikelnummer: CAY27297-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27297-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: Reinstoffe