CB-6644, CAS 2316817-88-4

Formulation: A solid

Formal Name: 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-benzamide

Purity: ≥98%

Formula Markup: C29H34ClFN4O5

Formula Weight: 573,1

Shelf life (days): 1460

CAS Number: 2316817-88-4

Notes: CB-6644 is an inhibitor of the RUVBL1/2 complex, a complex with ATPase activity that regulates several cellular processes, including chromatin remodeling and gene expression.{64382} It inhibits the ATPase activity of the RUVBL1/2 complex (IC50 = 15 nM) and is selective for the RUVBL1/2 complex over a panel of 224 ATPases at 10 µM. CB-6644 reduces viability in a panel of cancer cell lines with EC50 values ranging from 41 to 785 nM. It induces apoptosis in HCT116 colon cancer cells when used at a concentration of 0.4 µM. CB-6644 (150 mg/kg) reduces tumor growth in Ramos Burkitt’s lymphoma and RPMI-8226 multiple myeloma xenograft mouse models.

• Artikelnummer: CAY36125-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36125-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe