CCT020312, CAS 324759-76-4

Formulation: A solid

Formal Name: 6-bromo-3-[5-(4-bromophenyl)-1-[3-(diethylamino)-1-oxopropyl]-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone

Purity: ≥98%

Formula Markup: C31H30Br2N4O2

Formula Weight: 650,4

Shelf life (days): 1460

CAS Number: 324759-76-4

Notes: CCT020312 is an activator of eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3).{65219} It increases phosphorylation of eIF2α at serine 51 in HT-29 colon carcinoma and MCF-7 breast cancer cells when used at a concentration of 10 µM, an effect not seen in cells transfected with EIF2AK3 siRNA. It reduces phosphorylation of the tumor suppressor retinoblastoma (Rb) protein in HT-29 cells (EC50 = 5.1 µM). CCT020312 (10 µM) rapidly reduces the level of cyclin D1 in HT-29 cells. It also inhibits the growth of HT-29 cells (GI50 = 2.1 µM).

• Artikelnummer: CAY36577-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36577-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe