CD38 Inhibitor 1, CAS 1700637-55-3

Formulation: A solid

Formal Name: 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone

Purity: ≥98%

Formula Markup: C22H27N3O3S

Formula Weight: 413,5

Shelf life (days): 1460

CAS Number: 1700637-55-3

Notes: CD38 inhibitor I is an inhibitor of CD38 (IC50 = 17.7 nM).{68013} It is selective for CD38 over poly(ADP-ribose) polymerase 1 (PARP1), sirtuin 1 (SIRT1), and nicotinamide phosphoribosyltransferase (Nampt) when used at a concentration of 100 nM. CD38 inhibitor I (200 nM) increases NAD+ levels in mouse embryonic fibroblasts (MEFs). It decreases glucose and insulin levels in an intraperitoneal glucose tolerance test in 2-year-old, but not 1-year-old or 3-month-old, mice when administered at a dose of 10 mg/kg twice per day. CD38 inhibitor I prevents age-dependent decreases in exercise capacity and physical activity and increases in DNA damage in liver and skeletal muscle in mice.

• Artikelnummer: CAY35532-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35532-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe