CDDO methyl ester, CAS 218600-53-4

Formulation: A crystalline solid

Formal Name: 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid, methyl ester

Purity: ≥98%

Formula Markup: C32H43NO4

Formula Weight: 505,7

Shelf life (days): 730

CAS Number: 218600-53-4

Notes: The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.11 nM.{9897,20969} It induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells through inhibition of IκBα kinase/NF-κB signaling.{21755,21758} CDDO methyl ester has potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice and in Leprdb/db mice and triggering AMP-activated protein kinase and LKB1 activation in muscle and liver.{21757}

• Artikelnummer: CAY11883-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11883-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK