Cedazuridine, CAS 1141397-80-9

Formulation: A crystalline solid

Formal Name: (4R)-2′-deoxy-2′,2′-difluoro-3,4,5,6-tetrahydro-uridine

Purity: ≥98%

Formula Markup: C9H14F2N2O5

Formula Weight: 268,2

Shelf life (days): 1460

CAS Number: 1141397-80-9

Notes: Cedazuridine is an inhibitor of cytidine deaminase (IC50 = 0.4 µM).{66444} It increases plasma levels of decitabine via inhibition of its metabolism by cytidine deaminase in rhesus monkeys when administered at doses of 1 and 10 mg/kg. Cedazuridine (3 mg/kg) induces decreases in leukemic cell expansion in combination with orally administered 5-azacytidine (Item No. 11164), which is inactive as a single agent, in the bone marrow and spleen in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.{66445} Formulations containing cedazuridine in combination with decitabine have been used in the treatment of myelodysplastic syndrome (MDS).

• Artikelnummer: CAY38767-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38767-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK