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Celastrol , CAS 34157-83-0
Celastrol , CAS 34157-83-0
Artikelnummer
BPS27702-2
Verpackungseinheit
50 mg
Hersteller
BPS Bioscience
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Applications: Useful for inhibition of NF-κappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity.
CAS Number: 34157-83-0
Description: Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 µM). Cell permeable.
Format: Red powder
Purity: >98% by TLC.
Solubility: Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml)
Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.
Warnings: Protect from light. Protect from moisture. Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Sethi, G., et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κappaB-regulated gene products and TAK1-mediated NF-κappaB activation. Blood, 2007, 109:2727.
2. Westerheide, S.D. et al. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 2004. 279:56053.
3. Kiaei, M., et al. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2005, 2:246.
Applications: Useful for inhibition of NF-κappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity.
CAS Number: 34157-83-0
Description: Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 µM). Cell permeable.
Format: Red powder
Purity: >98% by TLC.
Solubility: Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml)
Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.
Warnings: Protect from light. Protect from moisture. Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Sethi, G., et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κappaB-regulated gene products and TAK1-mediated NF-κappaB activation. Blood, 2007, 109:2727.
2. Westerheide, S.D. et al. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 2004. 279:56053.
3. Kiaei, M., et al. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2005, 2:246.
| Artikelnummer | BPS27702-2 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27702-2 |
| Green Labware | Nein |
| Verpackungseinheit | 50 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
