Chidamide , CAS 743420-02-2

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Biological Activity: Chidamide has shown an IC50 ranging from 1 - 13 µM using an MTT assay performed on human cancer cell lines.

CAS Number: 743420-02-2

Description: Chidamide is a histone deacetylase inhibitor which increases Histone H3 acetylation levels in LoVo and HT29 colon cancer cells at low concentrations (4 µM). Chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6K, Raf and Erk 1/2 protein expression in colon cancer cells. Chidamide also dose-dependently upregulates p21 protein expression, down-regulates CDK4, and induces cell cycle arrest at the G0/G1 phase.

Format: White to off-white crystalline solid.

Purity: ≥98% by HPLC.

Solubility: Soluble in DMSO and DMF. Sparingly soluble in aqueous buffers. For maximum solubility, dissolve first in DMSO and then dilute with aqueous buffer of choice.

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Liu, L., et al., Biochem. Biophys. Res. Commun. 2010; 392: 190-195.
2. Wang, H., et al., Mol Med Report. 2012 Apr 5. doi: 10.3892/mmr.2012.858. [Epub ahead of print]

• Artikelnummer: BPS27202
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27202
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK